I am a postdoctoral researcher in our research group since January 2020. I am interested in understanding the presynaptic protein’s contribution towards the brain functions in healthy and diseased states. My current project deals with one of the important presynaptic protein Bassoon and its role in interneuron specific functions and dysfunctions towards learning and memory in mice. To this end, I will use state of art behavioural, biochemical techniques and pharmacological interventions in Bassoon knockout models.
Education
Bachelor of Science (B.Sc.) in Chemistry, Zoology and Biotechnology, Andhra University, India, 2007
Master of Science (M.Sc.) in Human Genetics, Andhra University, India, 2009
Master of Engineering (M.Eng.) in Biomedical Engineering, Martin-Luther-University and Anhalt University of Applied Sciences, Germany, 2013
PhD (Dr. rer. nat) in Neurobiology, Otto-von-Guericke-University, Germany, 2018
Postdoctoral Researcher, Leibniz Institute for Neurobiology, Germany, 2018-2019
Postdoctoral Researcher, Otto-von-Guericke-University, Germany, since January 2020 (CBBS-LSA fellow)
Contact Information
Email: anil.annamneedi[at]ovgu.de,
anil.annamneedi[at]lin-magdeburg.de
Telephone: +49(391)-67 55119
Publications
BSN (bassoon) and PRKN/parkin in concert control presynaptic vesicle autophagy. Autophagy. Epub ahead of print. doi: 10.1080/15548627.2020.1801259. * equal contribution
Hoffmann-Conaway S, Brockmann MM, Schneider K, Annamneedi A, Rahman KA, Bruns C, Textoris-Taube K, Trimbuch T, Smalla KH, Rosenmund C, Gundelfinger ED, Garner CC, Montenegro-Venegas C. (2020) Parkin contributes to synaptic vesicle autophagy in Bassoon-deficient mice. eLife 9:e56590. doi: 10.7554/eLife.56590.
Annamneedi A*, Caliskan G*, Müller S, Montag D, Budinger E, Angenstein F, Fejtova A, Tischmeyer W, Gundelfinger E.D, Stork O. Ablation of the presynaptic organizer Bassoon in excitatory neurons retards dentate gyrus maturation and enhances learning performance. Brain Struct Funct. 2018 Jun 18; 223:3423–3445. doi: 10.1007/s00429-018-1692-3. * equal contribution
Altmüller F, Pothula S, Annamneedi A, Nakhaei-Rad S, Montenegro-Venegas C, Pina-Fernández E, Marini C, Santos M, Schanze D, Montag D, Ahmadian MR, Stork O, Zenker M, Fejtova A. Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy. PLoS Genet. 2017 Mar 27;13(3): e1006684. doi: 10.1371/journal.pgen.1006684.
Meka DP, Müller-Rischart AK, Nidadavolu P, Mohammadi B, Motori E, Ponna SK, Aboutalebi H, Bassal M, Annamneedi A, Finckh B, Miesbauer M, Rotermund N, Lohr C, Tatzelt J, Winklhofer KF, Kramer ER. Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration. J Clin Invest. 2015 May;125(5):1873-85. doi: 10.1172/JCI79300.
LSA Fellow Project: Role of Bassoon in interneuron (dys-)function related to neuropsychiatric disorders. PI
LINseeds project: Comparative evaluation of the proteomic changes in different mouse strains lacking the pre-synaptic organizer Bassoon. Co-PI
